كتابة النص: الأستاذ الدكتور يوسف أبو العدوس - جامعة جرش قراءة النص: الدكتور أحمد أبو دلو - جامعة اليرموك مونتاج وإخراج : الدكتور محمد أبوشقير، حمزة الناطور، علي ميّاس تصوير : الأستاذ أحمد الصمادي الإشراف العام: الأستاذ الدكتور يوسف أبو العدوس
فيديو بمناسبة الإسراء والمعراج - إحتفال كلية الشريعة بجامعة جرش 2019 - 1440
فيديو بمناسبة ذكرى المولد النبوي الشريف- مونتاج وإخراج الدكتور محمد أبوشقير- كلية تكنولوجيا المعلومات
التميز في مجالات التعليم والبحث العلمي، وخدمة المجتمع، والارتقاء لمصاف الجامعات المرموقة محليا واقليميا وعالميا.
المساهمة في بناء مجتمع المعرفة وتطوره من خلال إيجاد بيئة جامعية، وشراكة مجتمعية محفزة للابداع، وحرية الفكر والتعبير، ومواكبة التطورات التقنية في مجال التعليم، ومن ثم رفد المجتمع بما يحتاجه من موارد بشرية مؤهلة وملائمة لاحتياجات سوق العمل.
تلتزم الجامعة بترسيخ القيم الجوهرية التالية: الإلتزام الإجتماعي والأخلاقي، الإنتماء،العدالة والمساواة، الإبداع، الجودة والتميّز، الشفافية والمحاسبة، الحرية المنظبطة والمستقبلية.
B.Sc. in pharmacy, Jordan University of Science and Technology, Irbid, Jordan, 1995. Graduated with an excellent average, GPA = 86%
involved the use of a multi-station tableting machine. In addition, solubility and dissolution profiles of these salts were characterized.
At the University of Iowa, for l semester as Teaching Assistant for Quantitative Research Methods of Analysis Lab for graduate students. This lab is designed for teaching the students how to run experiments on different instruments. Ten different methods of analysis were discussed in this lab.
Tablets can be subdivided by patients for several reasons. However, these subdivisions are not guaranteed to produce acceptable splits using the known subdivision techniques. The main objective of this study is to evaluate the use of bilayer tablets to obtain suitable tablet subdivisions. Bilayer tablets of two formulations were evaluated. The bilayer tablets were produced by compaction of 250 mg of powder at 43 MPa followed by compaction of an additional 250 mg of the same powder at 43 MPa. Each of the evaluated bilayer tablets was either composed of microcrystalline cellulose (MCC) or a mixture of MCC and caffeine. Subdivisions were performed by pressing the metal tip of a lancet on the edge of the bilayer tablet at the interface between the layers. Properties of the bilayer tablets and the subdivided layers were determined. Furthermore, the friability of the bilayer tablets was tested. It was found that the produced bilayer tablets lost less than 1% of their weight and did not delaminate during the friability test. Moreover, it was found that two almost intact tablets were subdivided from each bilayer tablet. The weight of each subdivision was close to 50% of the weight of the whole bilayer tablet. The standard deviations of the percentage weights of the subdivisions were less than or equal to 0.15%. Therefore, it was possible to subdivide bilayer tablets to produce tablet splits with relatively high accuracy and precision.
The objective of this study was to examine the impact of the physicochemical properties of the loaded drug or excipient, the concentration of Kollidon®SR (KSR), and the mechanical characteristics of KSR compacts on their disintegration times. Using disintegration apparatus, a two-hour constraint was chosen as the process's end point. Lactose-KSR compacts subjected to the highest compression pressure and Microcrystalline cellulose-KSR compacts with KSR concentrations exceeding 30% exhibited disintegration times of less than ten minutes. Likewise, compacts containing Diltiazem HCl-KSR demonstrated brief disintegration times across all tested KSR concentrations and compression pressures. Compacts of Modafinil, Metformin HCl, and
Kollidon® SR is one of the recent versatile coprocessed excipients in the formulation of modified-release dosage forms. It is prepared by co-spray drying aqueous dispersions of polyvinylacetate and polyvinylpyrrolidone. This article gives a critical review of the physicochemical attributes and technological properties of Kollidon® SR. The current review discusses various technological approaches used in the formulation with Kollidon® SR, from conventional ones like direct compaction and wet granulation to more advanced methodologies such as 3D printing, electrospinning and hot-melt extrusion. The review further elaborates on the influence of the major factors on drug release kinetics from Kollidon® SR-based formulations. Furthermore, this review unravels the potential of Kollidon® SR in the development of site-targeted oral drug delivery systems and focuses on its adaptability to other routes of administration. Further, the review deals with the considerations to be made regarding stability to make sure the formulations based on Kollidon® SR are reliable.
Background Periodontal bacteria occur in both planktonic and biofilm forms. While poor oral hygiene leads to accumulation of bacteria, reducing these microbes is the first step toward good oral hygiene. This is usually achieved through the use of mouthwash solutions. However, the exact antibacterial activity of mouthwash solution, especially when bacteria form biofilms, is yet to be determined. In this study, we evaluated the antibacterial activity of common mouthwash solutions against standard bacteria in their planktonic and biofilm states. Methods Standard bacterial strains were cultured, and biofilm were formrd. Thereafter, using standard method for determination of minimum inhibitory concentrations (MIC) values of various mouthwash solutions were determined. Results Results show that common mouthwash solutions have variable antibacterial activity depending on their major active components. Only mouthwash solutions containing chlorohexidine gluconate or cetylpyridinum chloride exhibited activity against majority, but not all tested bacterial strains in their biofilm state. Additionally, bacteria are generally less susceptible to all mouthwash solutions in their biofilm as compared to planktonic state. Conclusions While mouthwash solutions have variable antibacterial activity, bacteria in their biofilm state pose a challenge to dental hygiene/care where bacteria become not susceptible to majority of available mouthwash solutions.
In this study, a hardness tester was modified by attaching a metal blade to its testing area to obtain the minimum forces required to subdivide tablets along their diameters (F’). Moreover, the tensile strengths of subdividing tablets (TS’) were calculated. Tablets of microcrystalline cellulose (MCC) weighing 0.5 g were produced at applied compression pressures of 21, 31, 41, 50, and 60 MPa. In addition, tablets of Ludipress®, and a 5:2 mixture of paracetamol to MCC weighing 0.7 g were produced at applied compression pressures of 77, 116, 154, 193, and 232 MPa. It was found that F’ increased as the applied compression pressure used to produce the tablets increased until a maximum value was reached. This maximum value was at around 100 N for MCC and Ludipress® tablets and at around 76 N for paracetamol/MCC tablets. Moreover, a maximum value of TS’ was reached at a porosity of 0.37 for MCC, 0.15 for Ludipress®, and 0.11 for paracetamol/MCC tablets. The maximum TS’ values were at around 1.5 MPa for MCC and Ludipress® tablets and at around 0.9 MPa for paracetamol/MCC tablets. Therefore, both inter particulate bonding (tablet strength) and porosity (packing) affected the magnitudes of F’ and TS’.
Chitosan is a natural, biocompatible polymer. The aim of this work was to study the influence of drug solubility in 2% v/v acetic acid, formulation parameters, on mean hydrodynamic (MHD) diameters and drug entrapment efficiencies (% EE) into chitosan-TPP nanoparticles (NPs). Drugs of different aqueous solubilities with nearly similar molecular weights were chosen and admixed at several concentrations in 2% acetic acid at different chitosan concentrations and at fixed chitosan to TPP concentrations/volumes ratios. The NPs were freeze-dried, and the supernatants were utilized to determine % EE. Theophylline- and antipyrine-loaded NPs showed the best short-term physical stability in terms of MHD diameters. Antipyrine-loaded NPs possessed the larger MHD diameters, while vitamin C–loaded NPs showed the smallest ones. The relationships between the ratio of drug concentration relative to their solubilities in acetic acid were almost linear for antipyrine and vitamin C–loaded NPs when plotted against and the MHD diameters of NPs, and linear for antipyrine- and theophylline-loaded NPs when plotted against % EE with antipyrine NPs possessing the highest % EE. However, vitamin C– and propylthiouracil-loaded NPs exhibited curvilinear patterns with comparatively lower % EE. The concentration of chitosan, drug solubility in dispersion medium, and the ratio of the concentration of admixed drug relative to its solubility in dispersion medium were found critical in determining % EE and MHD diameters of NPs. It was evident that drugs with extremely low or high solubilities in dispersion medium resulted in low % EE when admixed at both low and high concentrations.
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Objective: The objective of this study was to evaluate the suitability of a ternary mixture of smart polymers comprised of Eudragit®E100, Eudragit®L100, and sodium alginate to serve as a carrier for sustained drug release for weakly basic drugs. The model drug chosen in this part of the study is Metronidazole.Methods: Matrix tablet formulations were prepared by either direct compression or by wet granulation. Dissolution studies were conducted using USP XXΠ rotating paddle apparatus in three different consecutive stages (pH 1.2, 4.8, and 6.8). Tablets made of low to intermediate proportions of sodium alginate and approximately equal proportions of Eudragit®E100 and Eudragit®L100 were found to have a significant modification of drug release rates.Results: Thus, indicating a potential for controlling the drug release for 12 hours depending on polymers ratios in the formulation. The ratio of sodium alginate to total Eudragit® polymers and the ratio of Eudragit®E100 to Eudragit®L100 within the ternary polymeric composition were found critical in determining the controlled release performance.Conclusion: Results of swelling studies were in agreement with the dissolution behaviors of the tablets. The findings suggest the significance of the ternary polymeric compositions in controlling the release of a weakly basic drug, Metronidazole.
Objectives To investigate the practice of tablet splitting and the frequency of using different techniques for tablet splitting at outpatient pharmacies in Jordan. Methods A structured questionnaire was used to interview adult patients who were prescribed at least one medication in a half-tablet dosage at two main outpatient pharmacies in the north of Jordan. Key findings A total of 491 patients were interviewed. The most commonly split medication was aspirin 325 mg (38.1%) followed by warfarin 5 mg (3.3%). The most common reason for tablet splitting was physician's order (41.2%). Additionally, (24.0%) of respondents sometimes skipped their doses due to tablet splitting difficulties. The majority of participants (n = 312, 63.5%) used their hands to split tablets. More than a tenth of the participants discarded parts of their tablets when splitting did not result in equal parts from their perspective. Conclusion Tablet splitting practice resulted in drug waste and medication non-adherence. Pharmacists are encouraged to educate other healthcare providers and patients about the practice of tablet splitting and when it is acceptable and when it is not.
Introduction: The use of self-medication represents a health problem among university students. Aim: This study aimed to explored the self-medication phenomenon among university students. Methods: Using a cross-sectional design and self-reported questionnaire, data were collected from 150 university students. Results: Use of self-medication was reported by 69.3% of the students. The most frequent medications used were analgesics (61.3%), cold & cough medications (58%) and antibiotics (56.7%), with the most common health conditions for self-medication being headaches (64.7%), colds and flu (62.7%), and fever (52.0%). The ease of access to medication (36.0%), advice from friends (32.7%), lack of time to consult physicians (27.3%), long waiting times for treatment (26.7%), hospital medications do not work (20.0%), and the hospital or clinic is very far away (18.7%) were reported by the students as reasons leading to self-medication. The most common sources for self-medication were pharmacies (58.7%), and available in home (49.3%), and hospital (31.3%). Conclusion: The use of self-medication is high among university students. Therefore, decision makers should pay more attention to this phenomenon and more education sessions should be given to youth to draw their attention to the possible negative effects of self-medication.
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