كتابة النص: الأستاذ الدكتور يوسف أبو العدوس - جامعة جرش قراءة النص: الدكتور أحمد أبو دلو - جامعة اليرموك مونتاج وإخراج : الدكتور محمد أبوشقير، حمزة الناطور، علي ميّاس تصوير : الأستاذ أحمد الصمادي الإشراف العام: الأستاذ الدكتور يوسف أبو العدوس
فيديو بمناسبة الإسراء والمعراج - إحتفال كلية الشريعة بجامعة جرش 2019 - 1440
فيديو بمناسبة ذكرى المولد النبوي الشريف- مونتاج وإخراج الدكتور محمد أبوشقير- كلية تكنولوجيا المعلومات
التميز في مجالات التعليم والبحث العلمي، وخدمة المجتمع، والارتقاء لمصاف الجامعات المرموقة محليا واقليميا وعالميا.
المساهمة في بناء مجتمع المعرفة وتطوره من خلال إيجاد بيئة جامعية، وشراكة مجتمعية محفزة للابداع، وحرية الفكر والتعبير، ومواكبة التطورات التقنية في مجال التعليم، ومن ثم رفد المجتمع بما يحتاجه من موارد بشرية مؤهلة وملائمة لاحتياجات سوق العمل.
تلتزم الجامعة بترسيخ القيم الجوهرية التالية: الإلتزام الإجتماعي والأخلاقي، الإنتماء،العدالة والمساواة، الإبداع، الجودة والتميّز، الشفافية والمحاسبة، الحرية المنظبطة والمستقبلية.
PhD in pharmaceutical technology- Near East University
MSc. in Pharmaceutical Science - Jordan University
BSc in pharmacy - Jordan university of science and technology
Objectives: The wound infection is a problematic issue that alter the healing of the wounds. Therefore, the prevention of bacterial growth and the enhancement of tissue regeneration are the key factors for the improvement of the healing process. Essential oils (EOs) showed strong activity against the growth of bacteria. This study was performed to evaluate the antibacterial effects of essential oils via their incorporation into a nanoemulsion (NE) system. Methods: Oregano and Rosemary oils were extracted and analyzed by GC-MS (Agilent Technologies, US) to elucidate the main active substance(s) of the oils. The antibacterial activity of the selected two EOs was assessed and compared through Disc Diffusion method (for inhibition zone) and Broth Microdilution method (for minimum inhibitory concentration) by conducting the oils on one of the most common bacterial strains that are associated with wounds; Pseudomonas aeruginosa. The oil with higher antibacterial activity was then incorporated in a nanoemulsion system. Droplet size, zeta potential, and PDI values were then evaluated. Results: The main active substance of Oregano and Rosemary oils that is responsible for the antibacterial activity was carvacrol (50.61%) and 1,8-Cineole (39.35%), respectively. The inhibition zone diameter was (10.5 mm) for oregano oil and (10 mm) for rosemary oil, while the MIC for oregano was (0.77 μg/ml) and for rosemary was (3.92 μg/ml). The optimum NE formulation achieved with oregano as an active ingredient and Kolliphor RH® 40 as a surfactant (BASF®, Ludwigshafen, Germany). The droplet size, zeta potential, and PDI results were 16.94 nm, -6.79 mV, 0.208 respectively. Conclusion: The obtained results showed that oregano oil is more effective than rosemary oil against the selected bacterium. Therefore, the bacterial growth in the wounds will be inhibited leading to speeding-up the inflammatory phase of the healing process, hence the overall integrity of the skin will be restored faster.
The research work was designed to develop a solid self-nanoemulsifying drug delivery system (S-SNEDDS) of deferasirox (DFX). According to the solubility studies of DFX in different components, Peceol, Kolliphor EL, and Transcutol were selected as excipients. Pseudo-ternary phase diagrams were constructed, and then SNEDDS formation assessment studies and solubility of DFX in selected SNEDDSs formulations were performed. DFX loaded SNEDDS were prepared and characterized. The optimum DFX-SNEDDS formulations were developed. The relative safety of the optimized SNEDDS formulation was examined in a human immortalized myelogenous leukemia cell line, K562 cells, using the MTT cell viability test. Cytotoxicity studies revealed more cell viability (71.44%) of DFX loaded SNEDDS compared to pure DFX (3.99%) at 40 μM. The selected DFX-SNEDDS formulation was converted into S-SNEDDS by adsorbing into porous carriers, in order to study its dissolution behavior. The in vitro drug release studies indicated that DFX release (Q5%) from S-SNEDDS solidified with Neusilin UFL2 was significantly higher (93.6 ± 0.7% within 5 min) compared with the marketed product (81.65 ± 2.10%). The overall results indicated that the S-SNEDDS formulation of DFX could have the potential to enhance the solubility of DFX, which would in turn have the potential to improve its oral bioavailability as a safe novel delivery system.
All Rights Reseved © 2023 - Developed by: Prof. Mohammed M. Abu Shquier Editor: Ali Mayyas
