كتابة النص: الأستاذ الدكتور يوسف أبو العدوس - جامعة جرش قراءة النص: الدكتور أحمد أبو دلو - جامعة اليرموك مونتاج وإخراج : الدكتور محمد أبوشقير، حمزة الناطور، علي ميّاس تصوير : الأستاذ أحمد الصمادي الإشراف العام: الأستاذ الدكتور يوسف أبو العدوس
فيديو بمناسبة الإسراء والمعراج - إحتفال كلية الشريعة بجامعة جرش 2019 - 1440
فيديو بمناسبة ذكرى المولد النبوي الشريف- مونتاج وإخراج الدكتور محمد أبوشقير- كلية تكنولوجيا المعلومات
التميز في مجالات التعليم والبحث العلمي، وخدمة المجتمع، والارتقاء لمصاف الجامعات المرموقة محليا واقليميا وعالميا.
المساهمة في بناء مجتمع المعرفة وتطوره من خلال إيجاد بيئة جامعية، وشراكة مجتمعية محفزة للابداع، وحرية الفكر والتعبير، ومواكبة التطورات التقنية في مجال التعليم، ومن ثم رفد المجتمع بما يحتاجه من موارد بشرية مؤهلة وملائمة لاحتياجات سوق العمل.
تلتزم الجامعة بترسيخ القيم الجوهرية التالية: الإلتزام الإجتماعي والأخلاقي، الإنتماء،العدالة والمساواة، الإبداع، الجودة والتميّز، الشفافية والمحاسبة، الحرية المنظبطة والمستقبلية.
دكتور استاذ مشارك
The detection of risk factors and the early diagnosis of renal failure are vital for the success of preventive therapeutic interventions. This study aimed to determine the potential association between uric acid (UA) levels and proinflammatory markers in patients undergoing hemodialysis (HD). Moreover, their possible role in premature diagnosis of renal injury (RI) was also evaluated. 50 HD patients and 24 healthy volunteers were included. UricasePAP test was used to measure UA. Tumor necrosis factor (TNF-α), interleukin6 (IL-6), and C-reactive protein (CRP) were measured by multiplex ELISA assay. The usefulness of UA and Pro-inflammatory markers for timely detection of renal damage was measured using the receiver operating characteristic (ROC) curve. Patients had significantly higher plasma concentrations of UA, TNF-α, IL-6, and CRP relative to volunteers. A positive correlation was found in HD patients between UA and TNF-α, and CRP, but there was no significant correlation between UA and the inflammatory markers in healthy controls. The area under the ROC curve for serum CRA was smaller than that for UA, demonstrating that UA may serve as a superior biomarker for early detection of renal injury in comparison to TNF- α. Nevertheless, serum CRP was found to be greater than both TNF-α and IL-6, the latter of which had a non-significant area under the ROC curve. Taken together, serum UA, CRP, and TNF-α—but not IL-6—are potentially early indicators for the diagnosis of RI. Moreover, serum UA is significantly elevated in HD patients and positively associated with inflammatory markers
Renal failure and kidney disease are major concerns worldwide and are commonly coupled to diseases like hypertension, diabetes, obesity, and hypercholesterolemia. We undertook this study to explore the scope of genetic spectrum underlying the physiopathology of end-stage renal disease (ESRD) using whole exome sequencing (WES) on genomic DNA (gDNA) from 12 unrelated patients in younger ages. We have performed WES on 12 patients in stage of ESRD and analyze the FASTQ data through GATK pipeline. Here, we report for the first time a novel approach of establishing the severity and the magnitude of a disease on different chromosomes and associated karyotypes using chromosome Heatmap. The chromosome Heat will provide us with a road map to narrow down mutations selection leading us to SNPs characterization. Our preliminary results presented in the form of chromosomes HeatMap prelude our ongoing works which consist in identifying and characterizing new genes involved in the problem of renal diseases, results that depict the magnitude of the uncovered genes mutations and their biological implications related to the genome of these patients.
Background and Aim: Gentamicin (GM) is one of the most effective antibiotics for severe, life-threatening Gram-negative infections. Nevertheless, its clinical use has been restrained because of its nephrotoxic potential. Royal jelly (RJ) and aliskiren (ALK) can individually prevent such toxic effects. The aim of this study was to explore the protective effects of a combination treatment of RJ and ALK on GM-mediated nephrotoxicity. Materials and Methods: Thirty-two adult female Wistar rats were divided equally into four groups: (I) Receiving normal saline; (II) GM (100 mg/kg, intraperitoneal [i.p.] injection); (III) GM (100 mg/kg, i.p. injection) plus ALK (50 mg/kg, i.p. injection); and (IV) GM (100 mg/kg, i.p. injection) plus ALK (50 mg/kg, i.p. injection) in combination with RJ (150 mg/ kg, orally). All treatments were administered daily for 10 days. The blood levels of creatinine, urea, uric acid, albumin, and total protein were measured. Then, the animals were sacrificed, and the kidneys were taken for histopathology. Results: Compared to normal control rats, GM-injected rats showed significantly (p<0.001) higher serum concentrations of uric acid, urea, and creatinine as well as evidently (p<0.001) lower blood levels of albumin and total protein. Moreover, GM administration was associated with significant renal histopathological changes. All these alterations were considerably (p<0.05) improved in GM-injected rats receiving ALK compared to rats receiving GM alone. However, when RJ was given in combination with ALK to GM-injected rats, it lessened the beneficial nephroprotective effects of both agents. Conclusion: The combination treatment of RJ and ALK is not desirable for GM-induced nephrotoxicity. Further studies are crucial to accurately explore the precise mechanism of RJ antagonistic interaction with ALK.
Background and Aim: Paracetamol (PCM) ingestion is one of the most frequent global causes of toxicity. Salvadora persica L. is a plant that among many other effects exhibits potent antioxidant, anti-inflammatory, antimicrobial, and anticancer effects. In this study, we investigated the possible protective effect of S. persica aqueous extract in the PCM overdose-induced liver and kidney injury and hematological changes in a mice model. Materials and Methods: Mice were given PCM with and without S. persica pretreatment. Blood cell counts and liver and kidney function biomarkers were measured. Liver and kidney samples were histologically examined. Results: A single overdose of PCM caused significant elevations of alanine and aspartate transaminases, alkaline phosphate, bilirubin, urea, uric acid, and creatinine compared with the control group. In addition, PCM toxicity significantly lowered red blood cell count but insignificantly increased both white blood cell and platelet counts in comparison to the control mice. Pretreatment with S. persica significantly prevented PCM-induced changes in hepatic and renal biomarkers. S. persica also caused marked reversal of hematological changes. Histologically, the liver and kidney showed inflammation and necrosis after PCM treatment, which were significantly reduced in mice pretreated with S. persica. Conclusion: Taken together, S. persica significantly inhibited PCM-induced renal, hepatic, and hematological toxicity, pointing to its possible use in the treatment of liver and renal disorders.
OBJECTIVE: Coronavirus 2019 (COVID-19) has now been declared as a worldwide pandemic. Currently, no drugs have been endorsed for its treatment; in this manner, a pressing need has been developed for any antiviral drugs that will treat COVID-19. Coronaviruses require the SARS-CoV-2 3CL-Protease (3CL-protease) for cleavage of its polyprotein to yield a single useful protein and assume a basic role in the disease progression. In this study, we demonstrated that punicalagin, the fundamental active element of pomegranate in addition to the combination of punicalagin with zinc (Zn) II, appear to show powerful inhibitory activity against SARS-CoV-2. MATERIALS AND METHODS: The 3CL protease assay kit was used to quantify 3CL protease action. The tetrazolium dye, MTS, was used to evaluate cytotoxicity. RESULTS: Punicalagin showed inhibitory action against the 3CL-protease in a dose-dependent manner, and IC50 was found to be 6.192 μg/ml for punicalagin. Punicalagin (10 µg/ mL) demonstrated a significant inhibitory activity toward 3CL-protease activity (p < 0.001), yet when punicalagin is combined with zinc sulfate monohydrate (punicalagin/Zn-II) extremely strong 3CL-protease activity (p < 0.001) was obtained. The action of 3CL-protease with punicalagin/Zn-II was decreased by approximately 4.4-fold in contrast to only punicalagin (10 µg/ mL). Likewise, we did not notice any significant cytotoxicity caused by punicalagin, Zn-II, or punicalagin/Zn-II. CONCLUSIONS: We suggest that these compounds could be used as potential antiviral drugs against COVID-19.
This study aims at investigating the Jordanian students’ knowledge, perceptions, and beliefs regarding e-cigarettes, as well as their motivation and triggers to try e-cigarettes in the future. A crosssectional study design was utilized using a questionnaire that was constructed and validated by the study investigators before the start of the study. Undergraduate and postgraduate students attending the Middle East University (MEU), Amman, Jordan were asked to fill in a questionnaire from February to May 2019. Out of 787 students who successfully completed the study questionnaire 75% were males and 25% were females. Most of the study participants were aware of the concept of the e-cigarette; however, only 28.1% of them were active smokers, and 15.8 % of them use/have ever used the ecigarettes. About 12% of the study participants were of medical background, and the majority of them were first- and second-year students. Most of the information acquired about e-cigarettes were from social media, followed by online advertising, and friends or family members. More than half of the participants rejected the idea of trying e-cigarettes in the future. Taken together; Jordanian students hold a good level of knowledge and perceptions regarding e-cigarettes. However, there is still a room for improvement and educational interventions. The good knowledge of students of medical background can help organizing social campaigns and public educational programs. Thus, the current study also highlights the pivotal role of social media nowadays, and enhances its consideration in any future interventions.
Coronavirus 2019 (COVID-19) pandemic has created a significant global challenge with respect to the search for specific and effective pharmacological agents with fewer adverse effects for treating this disease. To date, no effective therapy for COVID-19 has been established. Recent virological studies suggest an assortment of potential therapeutics, which could be good candidates for minimizing disease development. One of the most effective potential medications is Remdesivir, which has demonstrated in-vitro antiviral activity and is the first COVID-19 drug approved by the United States Food and Drug Administration (FDA). Adjunct medical care is used as an extra treatment method in addition to the essential treatment, for example, glucocorticoids, which cause a decline in the death rate in mechanically ventilated COVID-19 patients. More clinical preliminary studies should be conducted to explore the most effective pharmacological agent for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus causing COVID-19. Numerous possible drug-drug interactions (DDIs) that may take place with the COVID-19 repurposed drugs and other medications have been identified. These facts might be beneficial for physicians to screen and identify potential DDIs with adverse consequences, and accordingly styling preventive and management approaches for their avoidance.
Background: The high rate of death and sickness perceived in patients with end-stage renal disease is principally ascribed to the inadequacy of haemodialysis (HD), and this may relate to inadequate analysis of the factors affecting the HD process, including drugs taken by these patients. Aims and Objective: To explore the potential association of a dihydropyridine calcium channel blocker (amlodipine) and a beta-blocker prototype (propranolol) separately with the dialysis efficiency in HD patients. Methods: This is a retrospective study which include 275 (112 females and 163 males, 83% of whom also suffered from hypertension) patients with end-stage renal failure on haemodialysis. Patients were categorized into three groups: 125 patients taking amlodipine, 81 patients taking propranolol, and 69 patients not taking any of the above medications (controls). The HD efficiency, and the percentage reduction in creatinine, uric acid, and urea levels were compared between groups. Results: Compared with patients who were not receiving amlodipine or propranolol, a significant increase in the major HD adequacy marker which is the Kt/V ratio, as well as in the percentage reduction in creatinine, uric acid, and urea levels, was observed in patients taking amlodipine, but a significant decrease in these markers was detected in patients taking propranolol. Conclusions: Taken together, these findings indicate that the haemodialysis efficiency may be significantly improved (diminished) by supplementation with amlodipine (propranolol).
Vitamin D is one of the essential vitamins and has recently been demonstrated to be much more important for the appropriate functioning of the human body and well-being than initially believed. Although vitamin D is mainly known for its link with bone fractures and bone diseases, recent studies revealed that vitamin D and its analogues have revealed many pharmacological actions covering the regulation of cell growth, inhibition of inflammation, and improvement of neuromuscular function and immune function. Moreover, vitamin D and its analogues are reported to have role in different types of cancers, skin diseases, diabetes mellitus and infections caused by different bacterial and viral pathogens including SARS-CoV-2. The goal of this study is to evaluate the scientific literature on therapeutic uses of vitamin D and its analogues against different diseases and health condition. Special attention has been given to COVID-19 infection, cancer, skin diseases, and diabetes. The molecular mechanisms involved are also explored.
OBJECTIVE: Infectious bronchitis virus (IBV), for which no effective drugs are available, is among the most important causes of economic loss within the poultry industry. Apigenin is a flavonoid that can be isolated from plants. Apigenin has low toxicity with anti-viral activity. However, the effects of apigenin against IBV remain unclear. MATERIALS AND METHODS: Thus, here we investigate the anti-viral effect of apigenin on IBV using 10 day-old embryonated eggs by determining the virus titer by embryo infective doses50 (EID50/mL) and determining IBV genomes copy number (per µL) of allantoic fluid. RESULTS: We found that apigenin protected embryonated eggs from IBV. Additionally, apigenin reduced the log titer of the IBV with a significant correlation of up to 9.4 times at 2 µg/ egg. Also, apigenin appears to significantly reduce IBV genomes copy number (per µL) in the allantoic fluid. CONCLUSIONS: Apigenin may be a promising approach for the treatment of IBV, since it protects embryonated eggs from IBV in ovo and suppresses viral replication
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